Biodistribution and safety studies of a bicistronic plasmid
Biodistribution and security research of a bicistronic plasmid for nerve restore
Background: Gene remedy is one of many promising approaches for regenerative drugs. Native and long-term expression of important progress elements permits to realize the specified therapeutic impact. Nonetheless, some features of extended utilization of genetic constructs encoding progress elements, resembling toxicity, mutagenicity, genotoxicity and talent to disseminate from the injection web site and mediate ectopic expression of therapeutic proteins, are poorly investigated. These features of gene remedy medication utilization turned the topic of this examine. Experiment: To check plasmid biodistribution, toxicity, mutagenicity and genotoxicity we used beforehand described bicistronic genetic assemble encoding human mind neurotrophic issue (hBDNF) and urokinase plasminogen activator (huPA) for nerve restore. Biodistribution research had been carried out in mice: a course of intramuscular plasmid injections was adopted by the examine of the content material of the plasmid (Actual-time PCR) and recombinant proteins (ELISA) in murine organs and tissues. The examine of the plasmid continual toxicity was carried out on rats with registration of their weight dynamics, neurological standing, emotional state and blood assessments parameters. The mutagenicity of the plasmid was studied in an in vivo DNA comet take a look at in mice. Plasmid genotoxicity was investigated within the mannequin of somatic recombination in Drosophila females.
Outcomes: We’ve proven that plasmids can disseminate from the injection web site, however don’t mediate ectopic expression of progress elements upon repeated intramuscular injections. The studied plasmid additionally does not reveal poisonous, mutagenic or genotoxic results. Throughout the toxicological examine on rats, we’ve got proven that every day injections of this genetic assemble, regardless of its skill to disseminate from the injection web site, do not have an effect on the bodily, cognitive and emotional state of experimental animals.
Conclusions: We’ve demonstrated the security of the bicistronic plasmid, encoding hBDNF and huPA, upon its repeated administration. The properties of genetic constructs strongly depend upon their sequence and supply strategy, which requires conducting of their security research in every particular case.
Recombinant Thermobifida Fusca Cutinase(C-6xHis) |
|||
| CR10-50ug | Novoprotein | 50ug | EUR 496 |
|
Description: Supplied as a 0.2 μm filtered solution of 10mM Tris-HCl,1mM 2-mercaptoethanol,2mM MnCl2,150mM NaCl,pH7.5. |
|||
pLenti-CARM1 shRNA-2 Plasmid |
|||
| PVTBAV03691-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-CTLA4 shRNA-2 Plasmid |
|||
| PVTBAV05689-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-FOXM1 shRNA-2 Plasmid |
|||
| PVTBAV08732-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-JUN shRNA-2 Plasmid |
|||
| PVTBAV11741-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-LHX6 shRNA-2 Plasmid |
|||
| PVTBAV12881-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-MAGEA3 shRNA-2 Plasmid |
|||
| PVTBAV13661-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-RUNX3 shRNA-2 Plasmid |
|||
| PVTBAV20583-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-Slc7a11 shRNA-2 Plasmid |
|||
| PVTBAV21973-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-STAT3 shRNA-2 Plasmid |
|||
| PVTBAV22921-2 | Lifescience Market | 2 ug | EUR 356 |
pLenti-XRCC5 shRNA-2 Plasmid |
|||
| PVTBAV26238-2 | Lifescience Market | 2 ug | EUR 356 |
pET-dCas9-VP64-6xHis |
|||
| PVT17702 | Lifescience Market | 2 ug | EUR 300 |
pET-6xHis-(-30)GFP |
|||
| PVT17881 | Lifescience Market | 2 ug | EUR 341 |
pET- NLS- Cas9- 6xHis |
|||
| PVT10639 | Lifescience Market | 2 ug | EUR 301 |
Mouse Anti-6xHIS Tag monoclonal antibody |
|||
| CABT-BL8767 | Creative Diagnostics | 100ug | EUR 559 |
pDONR223-CD73 Plasmid |
|||
| PVTB00480-2 | Lifescience Market | 2 ug | EUR 356 |
Multi Fusion-Tagged recombinant Protein 52-Kda containing 16-tags (T-7, HSV, C-myc, VSV-G, Glu-Glu, V5, e-tag, Flag, S-tag, HA, KT3, E2, Au1, Au5, 6xHis-tags) for ELISA/Western |
|||
| MFPM52-C | Alpha Diagnostics | 100 ul | EUR 286 |
pCR4-TOPO-RNF135 Plasmid |
|||
| PVTB01189-2 | Lifescience Market | 2 ug | EUR 356 |
pGEM-Ltf(Q25R) Plasmid |
|||
| PVTB50084-2 | Lifescience Market | 2 ug | EUR 356 |
Plasmid Midi Kit I |
|||
| K1314-2 | Biovision | EUR 262 | |
Plasmid Midi Kit II |
|||
| K1315-2 | Biovision | EUR 262 | |
Plasmid ezFilter Mega3 Kit |
|||
| K1320-2 | Biovision | EUR 343 | |
Plasmid ezFilter Mega6 Kit |
|||
| K1321-2 | Biovision | EUR 370 | |
Plasmid ezFilter Mega10 Kit |
|||
| K1322-2 | Biovision | EUR 452 | |
pMD19-T-LEO1(E225G) Plasmid |
|||
| PVTB01141-2 | Lifescience Market | 2 ug | EUR 356 |
ToxOut? Endofree Plasmid Midi Kit |
|||
| K1328-2 | Biovision | EUR 207 | |
ToxOut? Endofree Plasmid Maxi Kit |
|||
| K1330-2 | Biovision | EUR 234 | |
ToxOut? Endofree Plasmid Mega3 Kit |
|||
| K1332-2 | Biovision | EUR 316 | |
ToxOut? Endofree Plasmid Mega6 Kit |
|||
| K1333-2 | Biovision | EUR 370 | |
ToxOut? Endofree Plasmid Mega10 Kit |
|||
| K1334-2 | Biovision | EUR 425 | |
Monoclonal Anti-Poly-His (6xhis) (His-tag) IgG |
|||
| HISP14-M | Alpha Diagnostics | 100 ug | EUR 482 |
pCDH-EF1-CymR-T2A-Puro (plasmid) |
|||
| QM200PA-2 | SBI | 10 ug | EUR 597 |
pCDH-EF1-CymR-T2A-Neo (plasmid) |
|||
| QM400PA-2 | SBI | 10 ug | EUR 581 |
Plasmid ezFilter Midi Kit I, Centrifuge |
|||
| K1316-2 | Biovision | EUR 262 | |
Plasmid ezFilter Midi Kit II, Centrifuge |
|||
| K1317-2 | Biovision | EUR 262 | |
Express Plasmid Midiprep Kit (25 min) |
|||
| K1323-2 | Biovision | EUR 262 | |
Express Plasmid Maxiprep Kit (25 min) |
|||
| K1324-2 | Biovision | EUR 283 | |
ToxOut? Endofree ezFilter Plasmid Midi Kit |
|||
| K1329-2 | Biovision | EUR 207 | |
ToxOut? Endofree ezfilter Plasmid Maxi Kit |
|||
| K1331-2 | Biovision | EUR 234 | |
ToxOut? Express Endofree Plasmid Midi Kit |
|||
| K1335-2 | Biovision | EUR 234 | |
ToxOut? Express Endofree Plasmid Maxi Kit |
|||
| K1336-2 | Biovision | EUR 262 | |
Phospholipid transfer Antibody |
|||
| 20-abx110096 | Abbexa |
|
|
Melanoma; Clone HMB45 (Concentrate) |
|||
| A00019-C.2 | ScyTek Laboratories | 0.2 ml | EUR 236 |
2-Propyl-β-D-glucuronide, 2 mg |
|||
| 0904-2 | AthenaES | 2 mg | EUR 162 |
Monoclonal Anti-Poly-His (6xhis) (His-tag) antibody, ascites |
|||
| HISP11-M | Alpha Diagnostics | 100 ul | EUR 482 |
HER-2 / c-erbB-2 / neu / CD340; Clone HRB2/451 (Concentrate) |
|||
| RA0108-C.1 | ScyTek Laboratories | 0.1 ml | EUR 125 |
HER-2 / c-erbB-2 / neu / CD340; Clone HRB2/451 (Concentrate) |
|||
| RA0108-C.5 | ScyTek Laboratories | 0.5 ml | EUR 300 |
Mitomycin C |
|||
| 2713-2 | Biovision | EUR 120 | |
IL-2 Interleukin-2 Human Recombinant Protein, His Tag |
|||
| PROTP60568-2 | BosterBio | Regular: 10ug | EUR 317 |
|
Description: Interleukin-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 133 amino acids fragment (21-153) having a molecular weight of 20kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. _x000D_ The IL-2 His is purified by proprietary chromatographic techniques._x000D_ |
|||
BMP-2 Bone Morphogenetic Protein-2 Human Recombinant Protein, Monomer |
|||
| PROTP12643-2 | BosterBio | Regular: 20ug | EUR 317 |
|
Description: Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, Polypeptide chain containing 115 amino acids (283-396) and having a molecular mass of 13009 Dalton. ;The BMP-2 is purified by proprietary chromatographic techniques. |
|||
PG LIVER 2 EA* |
|||
| 59423-2 | Pel-Freez | 2 EA | EUR 192.24 |
Individual Reaction Mix 2 |
|||
| G065-2 | ABM | 200 reactions | EUR 167 |
Rat cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E02C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Rat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rat cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E02C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Rat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rat cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E02C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Rat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Mouse cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E03C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Mouse cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E03C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Mouse cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E03C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Human cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E01C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Human cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Human cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E01C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Human cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Human cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E01C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Human cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Pig cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E07C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Pig cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E07C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Pig cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E07C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Goat cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E06C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Goat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Goat cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E06C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Goat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Goat cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E06C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Goat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E04C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E04C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E04C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Dog cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E08C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Canine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Dog cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E08C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Canine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Dog cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E08C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Canine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Monkey cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E09C0732-192T | BlueGene | 192 tests | EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Monkey cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E09C0732-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Monkey cholest erolester transfer protein/lipid transfer protein ELISA kit |
|||
| E09C0732-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Goat Anti-Poly-His (6xhis) (His-tag) IgG, aff pure |
|||
| HISP16-A | Alpha Diagnostics | 100 ug | EUR 408 |
Goat Anti-Poly-His (6xhis) (His-tag) IgG-FITC conjugate |
|||
| HISP16-FITC | Alpha Diagnostics | 100 ul | EUR 347 |
Rabbit Anti-Poly-His (6xhis) (His-tag) IgG-IR700DX conjugate |
|||
| HISP17-IR7 | Alpha Diagnostics | 100 ul | EUR 408 |
Phospholipid transfer Antibody (Biotin) |
|||
| 20-abx105774 | Abbexa |
|
|
Phospholipid transfer Antibody (FITC) |
|||
| 20-abx107192 | Abbexa |
|
|
Phospholipid transfer Antibody (HRP) |
|||
| 20-abx108612 | Abbexa |
|
|
Phospholipid transfer Polyclonal Antibody |
|||
| 42297-100ul | SAB | 100ul | EUR 333 |
pCMV-C-HA-Bcl-2 Plasmid |
|||
| PVTB00307-2c | Lifescience Market | 2 ug | EUR 356 |
Recombinant Human TFF-2 Protein |
|||
| PROTQ03403-2 | BosterBio | 20ug | EUR 317 |
|
Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma (Nikolaidis, N.M. et al. Am. Journal Respir. Cell Mol. Biol. (2003) 4: 458-464). Recombinant human TFF2 is a 12.0 kDa polypeptide of 107 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. |
|||
Recombinant Human Relaxin-2 Protein |
|||
| PROTP04090-2 | BosterBio | 25ug | EUR 317 |
|
Description: Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain. |
|||
Recombinant Murine IL-2 Protein |
|||
| PROTP04351-2 | BosterBio | 20ug | EUR 317 |
|
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant murine IL-2 is a 17.2 kDa protein, containing 149 amino acid residues. |
|||
Recombinant Human PAI-2 Protein |
|||
| PROTP05120-2 | BosterBio | 10ug | EUR 317 |
|
Description: PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions. The physiological relevance of this property, which is neither a consequence of any mutation in the PAI-2 gene nor associated with any known disorder, is still unclear. However, it appears that the formation of intracellular dormant polymers may be important for the controlled release of the inhibitor from PAI-2 producing cells. Plasma levels of PAI-2 are usually low or undetectable, except during pregnancy and in some forms of monocytic leukemia. Secretion of PAI-2 from the placenta normally occurs during the third trimester of pregnancy and accounts for the dramatic increase in PAI-2 levels (up to 250 ng/ml), which are maintained at these levels until postpartum, and then rapidly decline. In addition to its vital role in protecting the placenta from degradation by uPA and/or uPA-activated proteases, PAI-2 has been shown to be essential for the prevention of metastatic spread of neck, lung and breast cancers. The beneficial effect of PAI-2 seen in these studies is presumed to stem from its ability to inhibit uPA-dependent cell dissemination. PAI-2 has also been reported to inhibit keratinocyte proliferation, and to participate in the innate immune response during viral infection. Recombinant human PAI-2 is a 415-residue nonglycosylated protein. |
|||
Recombinant Human MMP-2 Protein |
|||
| PROTP08253-2 | BosterBio | 10ug | EUR 317 |
|
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids). |
|||
Mouse FGF-2 Recombinant Protein |
|||
| R00121-2 | BosterBio | 5ug/vial | EUR 259 |
|
Description: FGF basic (FGF2) is a multipotential fibroblast growth factor that stimulates and supports proliferation, migration and differentiation. Mouse FGF basic (FGF-2) Recombinant Protein is purified FGF basic (FGF-2) produced in yeast. |
|||
Chicken IL-2 Recombinant Protein |
|||
| R00387-2 | BosterBio | 5ug/vial | EUR 259 |
|
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Chicken IL-2 Recombinant Protein is purified interleukin-2 produced in yeast. |
|||
Recombinant Human BD-2 Protein |
|||
| PROTO15263-2 | BosterBio | 20ug | EUR 317 |
|
Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues. |
|||
Anti-ErbB 2/ERBB2 Antibody |
|||
| A00010-2 | BosterBio | 100ug/vial | EUR 334 |
Anti-Bcl-2/BCL2 Antibody |
|||
| A00040-2 | BosterBio | 100ug/vial | EUR 334 |
Anti-Angiopoietin-2/ANGPT2 Antibody |
|||
| A00370-2 | BosterBio | 100ug/vial | EUR 334 |
Anti-EIF4A1/2/3 Antibody |
|||
| A03922-2 | BosterBio | 100ug/vial | EUR 334 |
Emergence of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Coharboring a bla NDM-1-Carrying Virulent Plasmid and a bla KPC-2-Carrying Plasmid in an Egyptian Hospital
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Egyptian hospitals has been reported. Nonetheless, the genetic foundation and evaluation of the plasmids related to carbapenem-resistant hypervirulent Okay. pneumoniae (CR-HvKP) in Egypt haven’t been introduced. Due to this fact, we tried to decipher the plasmid sequences which might be accountable for transferring the determinants of carbapenem resistance, significantly bla NDM-1 and bla KPC-2 Out of 34 Okay. pneumoniae isolates collected from two tertiary hospitals in Egypt, 31 had been CRKP. Entire-genome sequencing revealed that our isolates had been associated to 13 completely different sequence varieties (STs). Essentially the most prevalent ST was ST101, adopted by ST383 and ST11.
Amongst the CRKP isolates, one isolate named EBSI036 has been reassessed by Nanopore sequencing. Genetic setting evaluation confirmed that EBSI036 carried 20 antibiotic resistance genes and was recognized as a CR-HvKP pressure: it harbored 4 plasmids, particularly, pEBSI036-1-NDM-VIR, pEBSI036-2-KPC, pEBSI036-3, and pEBSI036-4. The 2 carbapenemase genes bla NDM-1 and bla KPC-2 had been situated on plasmids pEBSI036-1-NDM-VIR and pEBSI036-2-KPC, respectively.
The IncFIB:IncHI1B hybrid plasmid pEBSI036-1-NDM-VIR additionally carried some virulence elements, together with the regulator of the mucoid phenotype (rmpA), the regulator of mucoid phenotype 2 (rmpA2), and aerobactin (iucABCD and iutA). Thus, we set out on this examine to research in depth the genetic foundation of the pEBSI036-1-NDM-VIR and pEBSI036-2-KPC plasmids. We report a high-risk clone ST11 KL47 serotype of a CR-HvKP pressure remoted from the blood of a 60-year-old hospitalized feminine affected person from the intensive care unit (ICU) in a tertiary care hospital in Egypt, which confirmed the cohabitation of a novel hybrid plasmid coharboring the bla NDM-1 and virulence genes and a bla KPC-2-carrying plasmid.
IMPORTANCE CRKP has been registered within the essential precedence tier by the World Well being Group and has turn into a major menace to public well being. The emergence of CR-HvKP is of nice concern by way of each illness and remedy. In-depth evaluation of the carbapenemase-encoding and virulence plasmids could present perception into ongoing recombination and evolution of virulence and multidrug resistance in Okay. pneumoniae Thus, this examine serves to alert contagious illness clinicians to the presence of hypervirulence in CRKP isolates in Egyptian hospitals.
Expression of Bacillus amyloliquefaciens transglutaminase in recombinant E. coli underneath the management of a bicistronic plasmid system in DO-stat fed-batch bioreactor cultivations
We studied the expression of Bacillus amyloliquefaciens transglutaminase cloned in Escherichia coli BL21(DE3)pLysS harboring the plasmid pBAD/3C/bTGase, a bicistronic expression system, in bioreactor cultivation. Batch and fed-batch managed as DO-stat methods had been employed for the manufacturing of the recombinant enzyme. In 30 h-batch cultivations utilizing Terrific broth (TB), 6 g/L of biomass and three.12 U/mgprotein of transglutaminase exercise had been obtained. DO-stat fed-batch cultivations underneath the management of oxygen focus (DO-stat) utilizing TB as medium however fed with glucose allowed the increment in biomass formation (17.5 g/L) and enzyme exercise (6.43 U/mgprotein).
DO-stat fed-batch utilizing mineral medium (M9) and fed with glucose underneath the identical circumstances produced even increased enzymatic exercise (9.14 U/mgprotein). The pH impact was investigated, and the perfect enzymatic exercise might be noticed at pH 8. In all cultivations, the bicistronic system remained secure, with 100% of plasmid-bearing cells. These outcomes present that E. coli bearing bicistronic plasmid constructs to precise recombinant TGase might be cultivated in bioreactors underneath DO-stat fed-batch utilizing mineral medium and it’s a promising technique in future optimizations to supply this necessary enzyme.
Ceftazidime-Avibactam Resistance in Klebsiella pneumoniae Sequence Sort 11 Resulting from a Mutation in Plasmid-Borne bla kpc-2 to bla kpc-33, in Henan, China
Function: Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major problem worldwide. Herein, we describe the evolution of ceftazidime-avibactam (CZA) resistance by sequencing scientific isolates from a affected person with CRKP an infection present process CZA remedy.
Sufferers and strategies: On this examine, six CRKP strains had been remoted from sputum and blood samples of a affected person with CRKP an infection after intracerebral hemorrhage. Two strains had been chosen for whole-genome evaluation.
Outcomes: Drug susceptibility testing confirmed that the MIC of CZA for CRKP strains remoted after 6 days of CZA remedy was 64-fold increased than that for 3 CRKP strains remoted earlier than CZA remedy (Four vs >256 μg/mL), whereas the MIC of imipenem and meropenem was 128-fold (>32 vs 0.25 μg/mL) and 16-fold (> 32 vs 2 μg/mL) decrease comparatively, respectively. Multilocus sequence typing confirmed that each one six CRKP strains remoted from the affected person had been ST11 and pulsed-field gel electrophoresis confirmed that they had been of the identical clone. Two strains had been chosen for whole-genome evaluation. The aspartic acid residue at place 179 within the Ω loop was changed by a tyrosine residue within the resistant pressure, and the plasmid carried a bla KPC-2 to bla KPC-33 mutation. The outcomes of the modified carbapenem inactivation methodology and the carbapenemase inhibitor enhancement and colloidal gold enzyme immunochromatographic assays for bla KPC-33 had been detrimental.
Conclusion: That is the primary report from Henan to point out that remedy with CZA for six days may cause mutations and alter the phenotype from CZA delicate to resistant. Due to this fact, routine testing for drug susceptibility and carbapenemase phenotypes must be carried out throughout remedy with CZA, and genotype dedication is crucial.
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC040958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF405S conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC470945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF647 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC470945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF647 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC470946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF647 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC470946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF647 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC470958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF647 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC470958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF647 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCAP0945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCAP0945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCAP0946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCAP0946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCAP0958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCAP0958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCB0945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Biotin conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCB0945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Biotin conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCB0946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Biotin conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCB0946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Biotin conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCB0958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Biotin conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCB0958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Biotin conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC810945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF680R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC810945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF680R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC810946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF680R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC810946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF680R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC810958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF680R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC810958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF680R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC700945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF770 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC700945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF770 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC700946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF770 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC700946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF770 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC700958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF770 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC700958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF770 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC880945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF488A conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC880945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF488A conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC880946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF488A conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC880946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF488A conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC880958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF488A conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC880958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF488A conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC610945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF660R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC610945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF660R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC610946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF660R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC610946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF660R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC610958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF660R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC610958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF660R conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC680945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF568 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC680945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF568 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC680946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF568 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC680946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF568 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC680958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF568 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC680958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF568 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCA0945-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), APC conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCA0946-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), APC conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCA0958-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), APC conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNUM0945-50 | Biotium | 50uL | EUR 395 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), 1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNUM0946-50 | Biotium | 50uL | EUR 395 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), 1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNUM0958-50 | Biotium | 50uL | EUR 395 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), 1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC050945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF405M conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC050945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF405M conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC050946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF405M conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC050946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF405M conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC050958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF405M conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC050958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF405M conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCP0945-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), PerCP conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCP0946-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), PerCP conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCP0958-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), PerCP conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCR0945-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), RPE conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCR0946-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), RPE conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCR0958-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), RPE conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNUB0945-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Concentration: 0.2mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNUB0945-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Concentration: 0.2mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNUB0946-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Concentration: 0.2mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNUB0946-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Concentration: 0.2mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNUB0958-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Concentration: 0.2mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNUB0958-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Concentration: 0.2mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC430945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF543 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC430945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF543 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC430946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF543 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC430946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF543 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC430958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF543 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC430958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF543 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCH0945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNCH0945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCH0946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNCH0946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCH0958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNCH0958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC550945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF555 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC550945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF555 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC550946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF555 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC550946-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF555 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC550958-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF555 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(DSD/958) Antibody |
|||
| BNC550958-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(DSD/958), CF555 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC940945-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF594 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(121-3) Antibody |
|||
| BNC940945-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(121-3), CF594 conjugate, Concentration: 0.1mg/mL |
|||
Double Stranded DNA (dsDNA)(AE-2) Antibody |
|||
| BNC940946-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against Double Stranded DNA (dsDNA)(AE-2), CF594 conjugate, Concentration: 0.1mg/mL |
|||
